Palladium and copper mediated cross couplings using dialkylphosphites

Fraser, Jamie (2013) Palladium and copper mediated cross couplings using dialkylphosphites. PhD thesis, University of Nottingham.

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Abstract

Described herein are synthetic methodologies using palladium- and copper-mediated cross coupling reactions involving dialkylphosphites.

Chapter 1 discloses two methods for producing alknylphophonates. The first is a novel palladium mediated cross coupling of alkynylbromides with dialkylphosphites. The second is an improvement of a known aerobic copper mediated cross coupling using terminal alkynes and dialkylphosphites.

Chapter 2 discloses a novel aerobic copper mediated amide synthesis method.

Chapter 3 discloses a novel aerobic copper mediated phosphoramidate synthesis method.

All of the above developed methodologies were found to produce their respective products in acceptable yields and tolerate a wide range of functionality.

The experimental section comprises the practical methods for effecting the above reactions and the experimental data for all of the compounds presented herein.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Hayes, C.J.
Woodward, S.
Faculties/Schools: UK Campuses > Faculty of Science > School of Chemistry
Item ID: 13586
Depositing User: EP, Services
Date Deposited: 11 Aug 2016 10:37
Last Modified: 14 Sep 2016 05:39
URI: http://eprints.nottingham.ac.uk/id/eprint/13586

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