The effect of silicon, silica and silicates on the osteoblast in vitro
Anderson, Susan Ita (2001) The effect of silicon, silica and silicates on the osteoblast in vitro. PhD thesis, University of Nottingham.
Silica is an essential trace element in human nutrition and dietary deficiency leads to abnormal bone formation in experimental animal studies (Carlisle, 1972, Schwartz 1972). Silica-containing glasses and glass ceramics, within a certain range, are bioactive, forming a strong bond with bone and soft tissue when they are used as bone replacement materials. The aim of this work was to investigate the effect of silica on the osteoblast in vitro with a view to its eventual incorporation into biomaterials to improve bone-bonding properties.
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