Using plasma polymerised allylamine to culture hepatocytes in in-vitro fluidic bioreactor
Dehili, Chafika (2008) Using plasma polymerised allylamine to culture hepatocytes in in-vitro fluidic bioreactor. PhD thesis, University of Nottingham.
Tissues constituting mammalian organisms are finitely organised 3-D multicellular structures where cell-cell and cell-matrix interactions are important modulators of functionality. The liver, being the site of metabolism in mammals, is extensively employed in in-vitro studies such as toxicology, drug testing and liver replacement. Most existing liver models have been static, homogenous 2-D models which have shown limited morphological and functional characteristics of in-vivo liver. With the improved understanding of the liver, these models became more sophisticated to comprise various liver and non-liver cell types, various configurations of extracellular matrix and complex scaffold supports, including fluidic systems.
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