The contribution of drug resistant cancer stem cells to paediatric brain tumoursTools Punjaruk, Wiyada (2010) The contribution of drug resistant cancer stem cells to paediatric brain tumours. PhD thesis, University of Nottingham.
AbstractIntroduction: Recent studies have revealed that cancer stem cells (CSCs) exist in malignant disease. Additionally, it is proposed that these cells may survive following chemotherapy, and hence contribute to tumour relapse. A significant mechanism of drug resistance in CSCs is believed to be the expression of ATP-binding cassette (ABC) transporters that efflux cytotoxic agents out of cells. The objective of this study was to study the existence of CSCs in a panel of primary paediatric brain tumours (PBTs) and to determine if these were drug resistant via functional ABC transporters.
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