Total synthesis of argyrin A and analogues thereof
Chen, Chou-Hsiung (2013) Total synthesis of argyrin A and analogues thereof. PhD thesis, University of Nottingham.
The cyclin dependent kinase inhibitor p27 is one of the most frequently dysregulated tumour suppressor protein in human cancers. A reduction in the level of cellular p27 is frequently due to increased proteasome-dependent degradation. Recently, studies show that the macrocyclic octapeptide argyrin A induced an increase in cellular p27 levels by preventing the turnover of the protein via inhibition of proteasome function.
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