Phosphorylcholine-based copolymer as synthetic vector for gene delivery
Lam, Jenny Ka-Wing (2006) Phosphorylcholine-based copolymer as synthetic vector for gene delivery. PhD thesis, University of Nottingham.
Gene therapy has a great potential for the treatment of a wide range of diseases. However, the development of a safe and efficient delivery vector is the major obstacle for gene therapy. Recently synthesized 2 - (dimethylamino) ethyl methacrylate 2-(methacryloxloxyethyl phosphorylcholine) (DMA-MPC) diblock copolymer was investigated in this work as a novel non-viral vector for gene delivery. It has been previously demonstrated that the cationic DMA block can condense DNA efficiently. The zwitterionic PC head groups are found naturally in the outer leaflet of biomembranes and are extremely biocompatible. It is thus proposed here that the MPC can act as a new steric stabilizer to the system.
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