The isolation, characterisation and investigation into the In vitro behaviour of human ocular vascular endothelial cells
Browning, Andrew C. (2013) The isolation, characterisation and investigation into the In vitro behaviour of human ocular vascular endothelial cells. PhD thesis, University of Nottingham.
Intraocular angiogenesis is associated with a number of common, blinding conditions including wet age-related macular degeneration, proliferative diabetic retinopathy, retinopathy of prematurity and rubeotic glaucoma. The pathogenesis of these disorders is centered on choroidal, retinal and iris microvascular endothelial cells (ECs) respectively. When studying these conditions, workers have applied conclusions from in vitro studies of human umbilical vein EC (HUVEC) and microvascular endothelial cells, derived from different species or organs. However it is now widely accepted that endothelial cells are very heterogeneous and .extrapolation of results from these cells may not provide reliable data applicable to human eye disease.
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