Regulation of skeletal muscle proteolysis
Slee, Adrian (2005) Regulation of skeletal muscle proteolysis. PhD thesis, University of Nottingham.
Proteolysis is a component of protein turnover, controlled by multiple proteolytic systems. Alterations in system components within skeletal muscle has been associated with hypertrophy, remodelling, atrophy, apoptosis and metabolic dysregulation. Key components may have novel regulatory roles, e. g. calpain-3 and cathepsin-L. Experiments described within this thesis investigated the hypothesis that the gene expression of specific proteolytic system components within skeletal muscle may be co-ordinately regulated and altered during nutritional and pharmacological states known to modify protein turnover and induce muscle growth.
Actions (Archive Staff Only)