Susceptibility mapping in high field MRI
Wharton, Samuel James (2011) Susceptibility mapping in high field MRI. PhD thesis, University of Nottingham.
Phase images of the human brain acquired using gradient echo based Magnetic Resonance Imaging techniques show excellent contrast at 7T. This contrast is attributed to small variations in magnetic susceptibility that perturb the main magnetic field and thus yield a spatial variation of the NMR frequency. The work described in this thesis is primarily concerned with mapping the distribution of magnetic susceptibility within the human brain using these phase images. The main technical challenges of the project were first to extract accurate field maps based on phase data, and then to solve the ill-posed problem of inverting these field maps to reconstruct susceptibility (ϰ) maps.
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