System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire

Figueredo, Grazziela and Aickelin, Uwe and Whitbrook, Amanda (2009) System dynamics modelling of the processes involving the maintenance of the naive T cell repertoire. In: Proceedings of the 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UK. Intelligent Modelling & Analysis (IMA), Nottingham, pp. 13-18.

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Abstract

The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immuno-degradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell repertoire and presents some preliminary results.

Item Type:Book Section
Schools/Departments:Faculty of Science > School of Computer Science
ID Code:1288
Deposited By:Aickelin, Professor Uwe
Deposited On:02 Feb 2012 10:30
Last Modified:02 Feb 2012 10:30

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