Design and synthesis of protein arginine methyltransferase inhibitors
Hong, Wei (2010) Design and synthesis of protein arginine methyltransferase inhibitors. PhD thesis, University of Nottingham.
Biological methylation is defined as the transfer of a methyl group from S-adenosyl-L-methionine(SAM) to one of a wide range of potential acceptors such as DNA, RNA, protein, hormones and neurotransmitters. Protein arginine methylation is a common post-translational modification facilitated by protein arginine methyltransferases(e.g. PRMTI). The roles of these enzymes in vivo are currently poorly understood.
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