Angiogenesis in the pathogenesis of inflammatory joint and lung diseases

Walsh, D.A. and Pearson, C.I. (2001) Angiogenesis in the pathogenesis of inflammatory joint and lung diseases. Arthritis Research, 3 (3). pp. 147-153.

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Abstract

This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process for growth and tissue repair after injury. Nevertheless, it may contribute to a variety of chronic inflammatory diseases, including rheumatoid arthritis, osteoarthritis, asthma, and pulmonary fibrosis. Inflammation can promote angiogenesis, and new vessels may enhance tissue inflammation. Angiogenesis in inflammatory disease may also contribute to tissue growth, disordered tissue perfusion, abnormal ossification, and enhanced responses to normal or pathological stimuli. Angiogenesis inhibitors may reduce inflammation and may also help to restore appropriate tissue structure and function

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Gardner, Mike
Date Deposited: 30 Jul 2004
Last Modified: 09 Oct 2007 15:49
URI: http://eprints.nottingham.ac.uk/id/eprint/126

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