An integrated approach to enhancing functional annotation of sequences for data analysis of a transcriptome
Hindle, Matthew Morritt (2012) An integrated approach to enhancing functional annotation of sequences for data analysis of a transcriptome. PhD thesis, University of Nottingham.
Given the ever increasing quantity of sequence data, functional annotation of new gene sequences persists as being a significant challenge for bioinformatics. This is a particular problem for transcriptomics studies in crop plants where large genomes and evolutionarily distant model organisms, means that identifying the function of a given gene used on a microarray, is often a non-trivial task. Information pertinent to gene annotations is spread across technically and semantically heterogeneous biological databases. Combining and exploiting these data in a consistent way has the potential to improve our ability to assign functions to new or uncharacterised genes.
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