The development of human primary hepatocyte model for investigating the pathogenesis of the hepatitis C virus
Dexter, Laura Joanne (2010) The development of human primary hepatocyte model for investigating the pathogenesis of the hepatitis C virus. PhD thesis, University of Nottingham.
The blood-borne virus, hepatitis C (HCV), is causing an increasing burden of chronic and terminal liver disease, world-wide. The development of successful drug treatments for this infection has been hampered by the lack of an efficient and physiologically relevant in vitro model of viral pathogenesis. The recent characterisation of the JFH1 clone of HCV, which is capable of both infection and replication in some types of cell lines, has revolutionised the potential of in vitro HCV research. Yet very few studies have been able to investigate the pathogenesis of HCV in normal, healthy hepatocytes, and none has examined the effects of such infection on other human liver cells.
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