Recombinant expression of functional mouse AhR LBD in E. coli
Elhawari, Wail (2012) Recombinant expression of functional mouse AhR LBD in E. coli. MPhil thesis, University of Nottingham.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic halogenated aromatic hydrocarbon, which is a potent toxin to different species such as fish, birds, and mammalians. TCDD exposure causes induction of cytochrome P4501A1 (CYP1A1), and that is controlled through the Aryl hydrocarbon receptor (AhR). AhR is a ligand-dependent cytosolic protein. It is a protein containing basic helix-loop-helix and Per-ARNT-Sim (PAS) domains. It is present in the cytosol as a complex containing two molecules of heat shock protein (hsp90) and AhR interacting protein (AIP).
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