The role of dopamine D2 and neuregulin-1 receptors in schizophrenia relevant phenotypes of cognition, attention and memory
Mathur, Naina (2012) The role of dopamine D2 and neuregulin-1 receptors in schizophrenia relevant phenotypes of cognition, attention and memory. PhD thesis, University of Nottingham.
Aberrant neurotransmitter function promotes cognitive deficits in schizophrenia. These abnormalities in functioning are seen as disruptions in attentional and information processing, as well as disruptions in the consolidation and retrieval of information. Tasks of attentional salience and memory that are used to model these disruptions include the latent inhibition (LI) task of attentional salience, prepulse inhibition (PPI) task of sensorimotor gating and an Episodic memory (EM) task, which is an index of memory for episodes at a particular point in time. Aberrant functioning of candidate genes that are associated with risk for schizophrenia may be seen as behavioural alterations in these tasks of schizophrenia relevant phenotypes. dopaminergic hyperactivity and hypofunction have been implicated in mediating disruptions on these cognitive tasks. Increased transmission in the dopamine system in the striatal region promotes schizophrenia symptoms, and indirect dopamine (DA) agonist Amphetamine worsens these symptoms in patients, and disrupts schizophrenia relevant behaviours on these cognitive tasks.
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