Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks

Hlinka, Jaroslav and Coombes, Stephen (2010) Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks. Physical Review Letters . ISSN 0031-9007 (In Press)

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Abstract

Ultra-slow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms.

Item Type: Article
Uncontrolled Keywords: Neural networks, Depolarization induced suppression of excitation, splay states, Morris-Lecar model, strong global coupling
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Mathematical Sciences
Depositing User: Coombes, Prof Stephen
Date Deposited: 27 Jan 2010 15:02
Last Modified: 23 Jun 2011 06:52
URI: http://eprints.nottingham.ac.uk/id/eprint/1227

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