Mathematical modelling of telomere dynamics
Qi, Qi (2011) Mathematical modelling of telomere dynamics. PhD thesis, University of Nottingham.
Telomeres are repetitive elements of DNA which are located at the ends of chromosomes. During cell division, telomeres on daughter chromomeres shorten until the telomere length falls below a critical level. This shortening restricts the number of cell divisions. In this thesis, we use mathematical modelling to study dynamics of telomere length in a cell in order to understand normal ageing (telomere shortening),Werner’s syndrome (a disease of accelerated ageing) and the immortality of cells caused by telomerase (telomere constant length maintenance).
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