Interleukin-4 receptor alpha gene variants and allergic disease

Hall, I.P. (2000) Interleukin-4 receptor alpha gene variants and allergic disease. Respiratory Research, 1 (1). pp. 6-8.

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
98Kb

Abstract

The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor alpha (IL-4Ralpha) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Ralpha polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme

Item Type:Article
Schools/Departments:Faculty of Medicine and Health Sciences > School of Medical and Surgical Sciences > Medicine
ID Code:122
Deposited By:Gardner, Mike
Deposited On:04 May 2004
Last Modified:09 Oct 2007 16:49

Repository Staff Only: item control page