Interleukin-4 receptor alpha gene variants and allergic disease

Hall, Ian P. (2000) Interleukin-4 receptor alpha gene variants and allergic disease. Respiratory Research, 1 (1). pp. 6-8.

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The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor alpha (IL-4Ralpha) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Ralpha polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Gardner, Mike
Date Deposited: 04 May 2004
Last Modified: 04 May 2020 20:32

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