Raman spectroscopy methods for investigating supported lipid bilayers
Sweetenham, Claire Sue (2011) Raman spectroscopy methods for investigating supported lipid bilayers. PhD thesis, University of Nottingham.
This work is centred on the development of Raman spectroscopy methods for investigating supported lipid bilayers (SLBs). These nanoscale, biological structures have found wide application as models of cellular membranes in many areas of scientific research. They consist of phospholipid molecules that self-organise into bilayer structures containing phase-separated microdomains, which play an important role in many biological processes. SLBs are well-defined and stable under a variety of conditions, allowing characterisation with a broad range of physical methods. However, many of these techniques provide purely a visualisation of the surface or disturb the bilayer with labelling. Raman spectroscopy can offer a non-invasive chemical and structural analysis of SLBs and microdomains.
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