Evaluation of an in vitro cytotoxicity assay for specific groups of chemicals
Smith, Lesley Mary (1991) Evaluation of an in vitro cytotoxicity assay for specific groups of chemicals. PhD thesis, University of Nottingham.
The FRAME KB cytotoxicity assay is an ill vitro test for basal cytotoxicity which measures the sub-lethal inhibition of cell growth by toxic substances. Exponentially growing 3T3-Ll mouse fibroblasts are exposed to a range of concentrations of a test substance for 72 hours, then relative cell number is estimated by the protein/kenacid blue dye-binding method.
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