The mannose receptor in macrophage biology
Gazi, Umut (2010) The mannose receptor in macrophage biology. PhD thesis, University of Nottingham.
The Mannose receptor (MR) is a type I membrane molecule involved in both haemostasis and pathogen recognition. Its extracellular domains have broad ligand specificities: the cysteine-rich (CR) domain is involved in sulphated sugar binding, the C-type lectin-like domains (CTLDs) are responsible for the detection of sugars terminated in mannose, fucose or N-acetylglucosamine, and the fibronectin-type II (FNII) domain mediates collagen binding.
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