Calpain-10 and insulin resistance in human skeletal muscle
Norton, Luke (2007) Calpain-10 and insulin resistance in human skeletal muscle. PhD thesis, University of Nottingham.
Variation in the calpain-10 gene has been linked to a three-fold increased risk for type 2 diabetes in Pima Indian and some European populations. Furthermore, reduced skeletal muscle expression of calpain-10 is associated with reduced insulin mediated glucose disposal and carbohydrate oxidation. The skeletal muscle specific calpain-3 plays a key role in skeletal muscle integrity and has also been linked to insulin resistance in humans and rodents.
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