Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression
Geeganage, Chamila and Bath, Philip M.W. (2009) Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression. Hypertension, 54 (4). pp. 775-781. ISSN 0194-911X
Both low and high blood pressure (BP) during the acute phase of stroke are associated independently with a poor outcome. Several small clinical trials have involved the alteration of BP and this study assessed the relationship between change in BP and functional outcome. Randomised controlled trials of interventions that would be expected, on pharmacological grounds, to alter BP in patients within one week of the onset of acute ischaemic or haemorrhagic stroke were sought using electronic searches. Data were collected on BP and clinical outcome. The relationship between the difference in on-treatment BP and odds ratios (OR) for outcomes was assessed using meta-regression.
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