Identification of genes conferring resistance to furan in Caenorhabditis elegans
Cai, Ning (2009) Identification of genes conferring resistance to furan in Caenorhabditis elegans. MSc(Res) thesis, University of Nottingham.
Furan is a heterocyclic organic compound which is a liver carcinogen in mice and rats, associated with short-term liver toxicity and hepatic pathology; however, the mechanism of induction of these acute effects by furan is unknown. The aim of this study was to examine the toxicity of furan in C. elegans and identify the genes in mutagenised C. elegans responsible for resistance to furan, with the aim of identifying a mechanism of action of furan as a toxin in C. elegans. It would then be possible to test if the mechanism of acute toxicity of furan in C. elegans and mammals is conserved.
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