Differentiation of embryonic stem cells through controlled release of growth factors from microspheres
olaye, eghosa omoregie andrew/ E A O (2009) Differentiation of embryonic stem cells through controlled release of growth factors from microspheres. PhD thesis, University of Nottingham.
The development of microspheres for the sustained delivery of protein and small drug delivery has been utilised in tissue engineering and drug delivery applications. However problems exist in obtaining a controlled and predictable release pattern of the encapsulated molecules from these materials. In this study, microspheres with a zero order release kinetic profile and no lag phase were developed from a novel PLGA based polymer blend.
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