A Comparison of Continuum and Cell-based Models of Colorectal Cancer
Walter, Alexander (2009) A Comparison of Continuum and Cell-based Models of Colorectal Cancer. PhD thesis, University of Nottingham.
Colorectal cancer is thought to originate in the epithelial cells that line the colorectal crypt and, in most cases, is associated with a mutation in Wnt-signalling pathway. These mutations cause cells to alter their proliferative behaviour, make their cytoskeleton less deformable and increase their levels of cell-cell and cell-substrate adhesion.
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