The development and application of biological models for evaluation of direct nose-to-brain drug delivery systems
Mistry, Alpesh (2009) The development and application of biological models for evaluation of direct nose-to-brain drug delivery systems. PhD thesis, University of Nottingham.
The olfactory neuroepithelium is the only part of the central nervous system that is exposed directly to the external environment. Therefore, it is the only non-invasive drug delivery route to the brain. Surface modification of PS nanoparticles with chitosan C-PS), polysorbate 80 (P80-PS) and polysorbate 80+FCS (P80-FCS-PS) changed the toxicity and distribution of these nanoparticles in olfactory mucosae. In addition, a reduction in nanoparticle diameter from 200nm to 20nm increased nanoparticle mucosal penetration and possibly also their cellular toxicity.
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