Molecular Basis of CYP2B2 Induction
Horley, Neill (1999) Molecular Basis of CYP2B2 Induction. PhD thesis, University of Nottingham.
Many structurally unrelated chemicals can induce members of the cytochrome P450 superfamily with phenobarbital (PB) being a typical example. PB induces CYP2B1/2, which are most highly expressed in the liver. Their mechanism of activation has not yet been elucidated, with advances hampered by the absence of a suitable cell culture system to mimic the in vivo PB-mediated induction.
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