Novel functionalized polymers for nanoparticle formulations with anti cancer drugs
Puri, Sanyogitta (2007) Novel functionalized polymers for nanoparticle formulations with anti cancer drugs. PhD thesis, University of Nottingham.
The chemistry and structure of Poly (glycerol adipate) facilitate its substitution with various pendant functional groups leading to modifications of the physicochemical properties of the polymer. Modified backbones then can be selected based upon the properties of the compound to be incorporated. Thus, this could be explored as a drug delivery system without many of the limitations of commercially available polymers. The aim of this study was investigate whether various polymers and drugs interact in a specific manner and whether the nature of these interactions influence the physicochemical characteristics of the particles and their drug loading and release profile.
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