Development of Cancer Immunotherapeutics Targeting Complement Regulatory Protein CD55
Bradley, Richard Grayson (2007) Development of Cancer Immunotherapeutics Targeting Complement Regulatory Protein CD55. PhD thesis, University of Nottingham.
CD55 is one of the complement regulatory/inhibitory proteins and is over-expressed on a wide range of solid tumours. CD55 is also known to be deposited within tumour stroma and is secreted in an active soluble form, mediated by matrix metalloproteinase-7. The complement cascade forms part of the innate immune system and culminates in cell lysis of targeted cells. As a complement regulatory protein, the primary function of CD55 is to accelerate the decay of complement components preventing formation of the membrane attack complex.
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